Inflammatory lymphadenopathies predicting renal cell carcinoma prognosis: association not so convincing yet

Renal cell carcinoma (RCC) is the most common cancer originating from the kidneys and is the most lethal genitourinary cancer (1). It is the ninth most common cancer worldwide (2). Almost 65,000 cases of RCCs are diagnosed in the United States annually (3). RCC is further classified into four independent entities based on histology i.e., clear cell carcinoma, papillary and chromophobe RCC and collecting duct RCC (4,5). Tumor node metastasis (TNM) system by American Joint Committee on Cancer (AJCC) is the most commonly used cancer staging system for RCC.