Article Abstract

Lactate as a key metabolic intermediate in cancer

Authors: L. Bruce Gladden


In 1985, George Brooks proposed the “Lactate Shuttle” (1), subsequently labeled the “Cell-Cell Lactate Shuttle” (2-4). In that initial treatise, relying largely on the use of isotopic tracers, he proposed a new concept for lactate (La) as a central player in metabolism during both rest and exercise.