Targeting selected extracellular matrix components to attenuate cardiac fibrosis

Simranjit S. Pattar, Ali Fatehi Hassanabad, Paul W. M. Fedak


Progressive fibrosis is a hallmark of heart failure and remains a central challenge in managing patients who have suffered from myocardial infarction (MI). Following ischemic injury to the heart, structural remodeling of the infarcted myocardium ensues.