Anticoagulation after mechanical aortic valve implantation: is it time to act after PROACT?

Mevlüt Çelik, Andras P. Durko, Stuart J. Head


Anticoagulation management after mechanical prosthetic heart valve (PHV) implantation should find the delicate balance between effectively preventing valve-related thromboembolic events while not substantially increasing the risk of bleeding (1). Mechanical PHVs traditionally require lifelong anticoagulation with vitamin K antagonists (VKAs).