Search for a reliable biomarker of acute kidney injury: to the heart of the problem

Luca Di Lullo, Biagio Raffaele Di Iorio, Claudio Ronco, Antonio Bellasi


Nephrologists are restlessly looking for an ideal biomarker of acute kidney injury (AKI). In particular, the search for a sensitive and specific “renal troponin” for a timely diagnosis of AKI is still an unmet need in the cardio-nephrology world. Unfortunately, under this premise, there is no one marker at the horizon ready to move into clinics and routine use at the current stage. This is probably due to a different biomarker-tissue selectivity of troponins and cardiac muscular tissue when compared to creatinine and renal tissue.