Article Abstract

Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers

Authors: Bob T. Li, Dennis Stephens, Jamie E. Chaft, Charles M. Rudin, David R. Jones, Valerie W. Rusch, Andreas Rimner, James M. Isbell


The current standard of adjuvant therapies for patients with early stage non-small-cell lung cancers largely depends on the stage of disease. Liquid biopsy for circulating tumor DNA (ctDNA) has the potential to detect minimal residual disease, depict genomic evolution, guide precision medicine to individual patients and revolutionize the management of early stage lung cancers. In light of the seminal work published by Abbosh and colleagues, we discuss the potential paradigm changing clinical implications of ctDNA, the biological and technological challenges to consider, and the future of ctDNA driven therapeutic studies.