Lysosomal function in β-cell survival during glucolipotoxicity
Type 2 diabetes (T2D) is an increasingly prevalent disease worldwide the incidence of which correlates in many cases with development of obesity. Elevated circulating free fatty acids (FFA) are thought to trigger key steps in development of insulin resistance and T2D (1). An early response to reduced insulin action in peripheral tissues is increased production and secretion of insulin by pancreatic β-cells, however, progressive β-cell loss and reduced insulin secretion lead to hyperglycemia and the complications associated with T2D (1). A factor contributing to loss of β-cells in T2D patients is increased apoptosis (2), which is thought to occur from chronic exposure to increased circulating glucose and FFA levels.