Article Abstract

Balanced crystalloids for the critically ill: knowledge on the rise but confusion still reigns!

Authors: Patrick M. Honore, Herbert D. Spapen


In a recently published retrospective study including a large cohort of postoperative and critically ill patients admitted in intensive care (IC), Zampieri et al. reported an association between infusion of a higher percentage of Lactated Ringer (LR) solution and less occurrence of acute kidney injury (AKI) and a reduced hospital mortality (1). The “protective” effect of LR was more pronounced as the total administered volume increased. Surviving patients received proportionally more LR and less normal saline (NS) than non-survivors.