Article Abstract

Drug-induced causes of secondary hypertension

Authors: Wilbert S. Aronow


Resistant hypertension is a blood pressure that remains above the treatment goal despite use of optimal doses of three antihypertensive drugs of different classes including a diuretic (1). Patients with resistant hypertension should be screened for causes of secondary hypertension (2). Common causes of secondary hypertension include renal parenchymal disease (1), renovascular disease (3), dug-induced causes (4), pregnancy (5), primary aldosteronism (6), and obstructive sleep apnea (7). Uncommon causes of secondary hypertension include acromegaly, hyperthyroidism, hypothyroidism, hyperparathyroidism, Cushing syndrome, apparent mineralocorticoid excess, pheochromocytoma/paraganglioma, carcinoid syndrome, congenital adrenal hyperplasia, coarctation of the aorta, and neurological causes (2). This article will discuss some of the drug-induced causes of secondary hypertension.