Article Abstract

Characterizing the contribution of inflammasome-derived exosomes in the activation of the immune response

Authors: Miguel Abal


The interaction of cells with the environment is well known and documented in different processes associated with the fate of the diseases. How do different cells from different organs with different and complex environments communicate in a global and integrative manner is a question that researchers from complementary scientific areas are trying to address over the past decades. Extracellular vesicles (EV), small vesicles secreted by most cell types, participate in intercellular communication allowing exchange of proteins, lipids and nucleic acids between the EV-producing and target cells. Among them, exosomes as vesicles with diameters of 30–150 nm intervene in the transfer of proteins, mRNAs, and miRNAs to recipient cells to mediate many biological processes. The impact of this type of intercellular communication and its relevance at the clinical setting is being recognized by the scientific community, and the role of exosomes as mediators of this interaction is becoming a new and exciting field of research with promise to address relevant clinical questions in the next future.


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