From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz


Sepsis is undoubtedly the most clinically challenging disease encountered in critically ill patients. The common consensus defines sepsis as a dysregulated host inflammatory response to an infectious agent (1). Sepsis is associated with mortality rates of around 30%, although these vary according to geographical location (2). There is no specific treatment for patients with sepsis, and management therefore relies on infection control—with source removal and effective antibiotics—along with organ function support (3).