Article Abstract

Combining traditional medicine and modern chemistry to fight malaria

Authors: Christiaan van Ooij

Abstract

A combination of traditional medicine and modern chemistry has provided a promising new lead in the search for new antimalarials. Using a rational chemical approach, Herman and colleagues (1) have identified the target of febrifugine, the active component in the ancient traditional medicine changshan, and modified the compound such that its side-effects are greatly reduced while the anti-malarial activity is maintained.