Article Abstract

Modifying therapy in patients with advanced Hodgkin’s lymphoma by integrating early metabolic response by interim PET-CT

Authors: Ulrike Bacher, Mascha Binder

Abstract

Hodgkin’s lymphoma shows an annual incidence of around 2-3 per 100,000 habitants in the Western hemisphere with a larger peak in younger adults between 20 and 30 years and a smaller peak in adults above 65 years. Although Hodgkin’s lymphoma is rare within the general population (accounting for less than 1% of all de novo neoplasms occurring every year worldwide) (1), it belongs to the most frequent malignancies in young adults and represents the most frequent hematological malignancy in this age group (2). Outcomes of patients with Hodgkin’s lymphoma in general are favorable, with the vast majority of patients achieving permanent cure by standard therapies. Survivors, however, may face the problems caused by late toxicities such as secondary tumors or cardiovascular complications.

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