Article Abstract

Ischemia-reperfusion injury: evidences for translational research

Authors: Francesco Bellanti

Abstract

First used in the early nineteenth century, the term ischemia refers to impaired blood supply to tissues caused by reduced or obstructed arterial inflow. Restoration of blood flow at the earliest remains the cornerstone of all current treatment options to ischemia, nevertheless reperfusion may paradoxically induce and worsen ischemic tissue damage, leading to ischemia-reperfusion injury (IRI). IRI contributes to pathology in a wide range of conditions, such as single organ infarction and revascularization (stroke; myocardial, renal, intestinal infarction), multiple organ ischemia-reperfusion (trauma, circulatory arrest, sickle cell disease, sleep apnea), organ transplantation or surgery (1).

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